1) You tone is only as good as the weakest link in your signal chain
2) A good instrument/amp etc is a sum of ALL the parts.
WARNING.. long dissertation rambling to follow

First off let me begin by saying, I firmly believe that the statement 'tone is in your hands' is NOT true. I believe this fallacy was started twofold. First someone hears their hero playing with a setup different than their 'normal' setup, and of course the hero sounds like the hero-- in this case, the person is mistaking 'style' for 'tone' Secondly, say I wanted to have the tone that Buddy had on 'the black album', so I buy me a push pull, and a fender twin, plug in using his exact setup, and my tone is not what I hear when I play the record. LEts see, what is the missing link here... most would assume my 'hands' sure I wont have his style, but I shodl be able to get the same tone, but here I have some 'missing links' in the tone spectrum.. What am I missing? First, what cables was he using? Ok so I have ht same cables, I am also not factoring in: 1) the mic he used, 2) mic placement, 3) the mixing console and settings, 4) outboard effects, 5) tape coloration, 6) final mixing eq settings 7) artifacts from mastering from tape to vinyl
Another pet peeve of mine is that 'you have to use george L's cable because it retains more high end' etc. Well that is fine, but a lot dont realize that 1) the connectiosn are not perfect being the slip on type, corrosion can and does happen. Some folks use the unplated brass ends, the corrosion will change the tone, and more importantly, add in any active effects, and the quality of this cable is not really needed, since a buffer amp will override most of the advantages. I laugh at a lot of 6 stringsrs I see running 10 or so Boss, DOD etc effects, all with buffered circuitry (i.e. the effect even when bypassed affects the tone), and they have to have the GeorgeL's cables between every effect. Overkill. the short 6" interconnects do not matter when running this many buffered effects. Not to mention, tha tmany buffered effects WILL kill your tone, no matter WHAT cables you use! True bypass is another topic for another time. One final note on cables, the most critical point for any cableing woudl be the longest run BEFORE any buffering. SO say you have a matchbox plugged into your steel. PRetty much anything from ther to the amp isn't as big of a deal as one would think, hwoever, the BIG deal is the wire from the pickup, to the controls, to the output jack (not to mention losses in the switches, pots and jacks!!). Why is it that soem of the best (read most expensive) commercially made pickups, use the junkiest wire possible (Duncan, Dimarzio etc, even Bill Lawrence uses unshielded wire, relying on the instrument to provide shielding, but he knows that cheap shielded cable is detrimental to tone... Jerry Wallace is the only guy I know who uses the best quality shielded cable on his pickups). Look to improve HERE first for your tone, where it's the most critical)
And lets look at amps. Say we were using a twin, just like buddy did, and say we could magically be in the same room when he recorded, and we find our setup, identicl to his dont sound exactly the same. Why again? his hands? Nope, we are talking TONE not style here. So we dig into the amps and find the amps both have 10% and 20% tolerance components, LOTS of room for varation there... next we look at tubes, we could be suing differnt brands, different age tubes, and even tubes of different runs all sound a LITTLE different, not to mention, how hot is his amp biased? how hot is mine? are the connectors dirty on ANY of our cables?
I could pick up a Franklin, plug into a mesa preamp, and I'd bet my tone is nothing like Mike Johnson or Paul Franklin's tone, heck I could even use a profex with the Newman presets, but I wont have THEIR tone.. it's not because of my hands, but maybe due to what the studio engineers do to the tone at that point, the artifacts from the digitization..
Point is, we can all strive for the tone we like, we can even use the setup of our heroes, but even if they sat in using our gear, I think we would all be surprised that yes, they will sound like themselves, but the tone would NTO be the same as the old recording we know and love so dearly.. Does that mean we can't get a good tone? I would say contrary to what we are striving for, if you play a good sounding and set up guitar, through a good sounding amp, you can and will have good tone. In fact, I would venture as much as to say you can have a BETTER tone than what is on the records, if only for the fact, your signal chain is less cluttered, and you have less taking away from the pure tone your ears are hearing. Plug a push pull through a volume pedal into an odl Twin, or Session 400, and you'll get goosebumps. Plug an old ShoBud into an old Fender, and you'll get lost in the rich full tone you hear, overtones and harmonics that are simply lost through the recording processes (compression, colroation, artifacts etc).

